Question

state the significanes of glucose alanine cycle​

Answer 1

Answer:

Functions of the glucose-alanine cycle

It transports nitrogen in a non-toxic form from peripheral tissues to the liver. It transports pyruvate, a gluconeogenic substrate, to the liver. It removes pyruvate from peripheral tissues. This leads to a higher production of ATP from glucose in these tissues.

Explanation:

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Answer 2

Answer:

The glucose-alanine cycle, or Cahill cycle, proposed for the first time by Mallette, Exton and Park, and Felig et al. between 1969 and 1970, consists of a series of steps through which extrahepatic tissues, for example the skeletal muscle, export pyruvate and amino groups as alanine to the liver, and receive glucose from the liver via the bloodstream.

The main steps of the glucose-alanine cycle are summarized below.

When in extrahepatic tissues amino acids are used for energy, pyruvate, derived from glycolysis, is used as amino group acceptor, forming alanine, a nonessential amino acid.

Alanine diffuses into the bloodstream and reaches the liver.

In the liver, the amino group of alanine is transferred to α-ketoglutarate to form pyruvate and glutamate, respectively.

The amino group of glutamate mostly enters the urea cycle, and in part acts as a nitrogen donor in many biosynthetic pathways.

Pyruvate enters gluconeogenesis and is used for glucose synthesis.