Question

state the user of isoples​

Answer 1

Radioactive isotopes have many useful applications. In medicine, for example, cobalt-60 is extensively employed as a radiation source to arrest the development of cancer. Other radioactive isotopes are used as tracers for diagnostic purposes as well as in research on metabolic processes.

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Answer 2

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Isoplex 4% w/v Solution for Infusion

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Beacon Pharmaceuticals

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Active ingredient

succinylated gelatin

Legal Category

POM: Prescription only medicine

SmPC

Patient Leaflet

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This information is intended for use by health professionals

1. Name of the medicinal product

Isoplex 4% w/v Solution for Infusion

2. Qualitative and quantitative composition

Succinylated gelatin (Modified Fluid Gelatin) 4% w/v in Water for Injections, also containing electrolytes.

Electrolytes

Sodium ion (Na+)

145 mmol/litre

Chloride ion (Cl¯)

105 mmol/litre

Lactate ion

25 mmol/litre

Potassium ion (K+)

4 mmol/litre

Magnesium ion (Mg2+)

0.9 mmol/litre

3. Pharmaceutical form

Sterile non-pyrogenic solution for infusion.

A clear pale yellow or straw coloured solution contained within a flexible infusion bag.

Key Physico-chemical properties:

Weight average molecular weight (Mw)

30 000 Dalton

Number average molecular weight (Mn)

20 000 Dalton

pH

7.4 + 0.5

Osmolarity

284 mOsm/litre

4. Clinical particulars

4.1 Therapeutic indications

Isoplex is a colloidal plasma substitute indicated for the initial management of hypovolaemic shock caused by, for example, haemorrhage, acute trauma or surgery, burns, sepsis, peritonitis, pancreatitis or crush injury.

Isoplex may be used in the initial treatment of blood loss during pregnancy where plasma volume replacement is needed.

4.2 Posology and method of administration

Isoplex is administered intravenously; the volume and rate of infusion will depend on the condition of the patient. The rate of administration can be increased by the application of pressure to the container or by adjusting the giving set pump. When given rapidly Isoplex should be warmed to no more than 37°C if possible. In severe acute blood loss, Isoplex may be given rapidly (500 ml in 5 – 10 minutes) until signs of hypovolaemia are relieved. When large volumes are given, suitable monitoring should be used to ensure that an adequate haematocrit is maintained (the haematocrit should not be allowed to fall below 25%) and that dilutional effects upon coagulation are avoided. (Expert haematological advice should be sought, especially in cases of massive blood loss).

For massive fluid loss, Isoplex may be used concomitantly with blood, the rate and amount of which depends on the clinical condition of the patient. The haemodynamic status of the patient should be monitored.