statin is work as competative inhibitor
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Abstract. Objective: HMG-CoA reductase inhibitors (statins) possess anti-inflammatory and immunomodulatory properties that are independent of their lipid-lowering action. ... Conclusion: Statins decrease CD40 expression and CD40-related activation of vascular cells.
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Another class of drugs that demonstrates immunosuppressive activity includes the statins. Statins inhibit 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase, are effective lipid lowering agents, and they can also modulate the immune response. ... Statins do not have an effect on MHC-I expression.
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