Question

Structure of organic compounds containing functional groups hydroxyl and nitrile

Answer 1

Answer:

Pradip K Mascharak

Coordination Chemistry Reviews 225 (1-2), 201-214, 2002

Nitrile hydratase, the enzyme involved in microbial nitrile assimilation, comprises either one non-heme low-spin iron(III) or a non-corrinoid cobalt(III) center at the active site. Two carboxamido nitrogens, one cysteine-sulfur, and two sulfurs from a cysteine-sulfenic (Cys-SO) and a cysteine-sulfinic (Cys-SO2) acid moiety respectively constitute the donor set around the metal center of this hydrolytic enzyme. Binding of one molecule of NO at the sixth site of the iron(III) center modulates the activity of the enzyme. It is suggested that a metal-bound …