Sulfa drugs causing polymerization of mutant hemoglobin molecule in sickle cell anemia
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Pathogenesis. Sickle cell disease is characterized by a structural abnormality in the beta-globin chain of the hemoglobin molecule within the red blood cells (RBCs). The sickle mutation is a single base change (GAT → GTT) in the sixth codon of exon-1 of the beta-globin gene on chro
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