Supercoiling refers to the extra turns in the structure of ds DNA due to the action of
A.DNA gyrase
B. DNA pyrase
C. RNA gyrase
D. RNA pyrase
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Two classes of antibiotics that inhibit gyrase are: The aminocoumarins (including novobiocin). Aminocoumarins work by competitive inhibition of energy transduction of DNA gyrase by binding to the ATPase active site located on the GyrB subunit. The quinolones (including nalidixic acid and ciprofloxacin).
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