synergic effect of CO
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the dual-therapy with CO and BV was more effective than monotherapy in protecting HTx and KTx against I/R injury after prolonged cold ischemia. Enhanced effectiveness appeared to be provided by the different mechanisms of CO and BV to exert protection against I/R injury. The study may also suggest that the potent cytoprotection of HO-1 attributes to the different actions of byproducts of heme catabolism to mediate
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