Question

Synthesis and evaluation of -aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis

Answer 1

However, potent new anti-TB drugs with new mechanism of action have not been Treatment for multidrug-resistant TB is long- lasting, less effective, costly, and poorly tolerated.

Answer 2

The need to synthesize new drugs that will shorten the total duration of effective treatment and/or significantly reduce the dosage taken underGeneral scheme of FAS-II system involved in mycolic acids biosynthesis … The pyridyl amides 6a, 6d synthesized showed the same trends as the corresponding linear amides … cinnamic derivatives may be regarded as interesting leads in the design and synthesis of M …