Question

Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives

Answer 1

Two series of novel substituted imidazole derivatives containing substituted pyrazole moiety were synthesized, characterized and their antimicrobial studies were performed.

Answer 2

Abstract In the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a–d and 5a–j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a–d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a–e) with 1, 2-diketones (4a, b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for