Question

synthesis of rampicin
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Answer 1

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Answer 2

Answer :-

• Abstract

AbstractRifampicin is an important drug against tuberculosis, with large market demand. To improve the quality of rifampicin, the rifampicin synthesis process via oxazine, which is widely used in China, is studied and optimized. Rifampicin can be synthesized through cyclization and condensation reactions of rifamycin S that is prepared directly by oxidation and extraction of zymotic fluid, which is simpler without the crystallization, separation, drying and acidification for rifamycin S sodium salt compared with the traditional process that uses rifamycin S sodium salt as raw material. The effects of temperature and time of cyclization, temperature and time of condensation, ratios among raw materials and dosage of catalyst on the yield rate and purity of rifampicin product are investigated.

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