Biology, asked by Shubhjot3474, 1 year ago

Targeted activation of the shp-1/pp2asignaling axis elicits apoptosis of chroniclymphocytic leukemia cells ppt

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Answered by ItsCuteBoy

Answer:

Nintedanib directly activates SHP-1 in the cytosol of chronic lymphocytic leukemia cells. We previously demonstrated that SHP-1 is present in CLL cells in two forms, one bound to the plasma membrane receptor CD5 in an active state, and the other in the cytosol in an inhibited conformation.

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