Question

The acid dissociation constant of uric acid is
K = 4.0 x 10-6 M. The pH of a sample is 6.0. What
is the ratio of urate ion to uric acid in the urine
(1) 2.0
24.0
(3) 6.0
(4) 0.25
1​

Answer 1

Explanation:

rise in pH depended solely on the increase of urate anion. As much as 220 mg./dl. of uric acid could be dissolved for 24 hours at pH 7.0. But following seven-day incubation the total dissolved urate concentration decreased to 16 mg./dl. due to NaU crystallization.