Biology, asked by banerjeeshri4340, 1 year ago

The amount of chemical or drug administered animal per unit body weight is described as

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Answered by QHM
1

ANSWER:-

The LD50 is usually expressed as the mass of substance administered per unit mass of test subject, typically as milligrams of substance per kilogram of body mass, but stated as nanograms (suitable for botulinum), micrograms, milligrams, or grams (suitable for paracetamol) per kilogram.

Answered by Anonymous
0

The LD50 is usually expressed as the mass of substance administered per unit mass of test subject, typically as milligrams of substance per kilogram of body mass, sometimes also stated as nanograms (suitable for botulinum), micrograms, or grams (suitable for paracetamol) per kilogram.Note: Comparing substances (especially drugs) to each other by LD50 can be misleading in many cases due (in part) to differences in effective dose (ED50). Therefore, it is more useful to compare such substances by therapeutic index, which is simply the ratio of LD50 to ED50.[citation needed]

The following examples are listed in reference to LD50 values, in descending order, and accompanied by LC50 values, {bracketed}, when appropriate.

Substance Animal, Route LD50

{LC50}

LD50 : g/kg

{LC50 : g/L}

standardized Reference

Water rat, oral >90,000 mg/kg >90 [6]

Sucrose (table sugar) rat, oral 29,700 mg/kg 29.7 [7]

Glucose (blood sugar) rat, oral 25,800 mg/kg 25.8 [8]

Monosodium glutamate (MSG) rat, oral 16,600 mg/kg 16.6 [9]

Stevioside (from stevia) mice and rats, oral >15,000 mg/kg >15 [10]

Vitamin C (ascorbic acid) rat, oral 11,900 mg/kg 11.9 [11]

Glyphosate (isopropylamine salt of) rat, oral 10,537 mg/kg 10.537 [12]

Lactose (milk sugar) rat, oral >10,000 mg/kg >10 [13]

Aspartame mice, oral >10,000 mg/kg >10 [14]

Urea rat, oral 8,471 mg/kg 8.471 [15]

Cyanuric acid rat, oral 7,700 mg/kg 7.7 [16]

Cadmium sulfide rat, oral 7,080 mg/kg 7.08 [17]

Ethanol (Grain alcohol) rat, oral 7,060 mg/kg 7.06 [18]

Sodium isopropyl methylphosphonic acid (IMPA, metabolite of sarin) rat, oral 6,860 mg/kg 6.86 [19]

Melamine rat, oral 6,000 mg/kg 6 [16]

Methanol rat, oral 5,628 mg/kg 5.628 [20]

Taurine rat, oral >5,000 mg/kg >5 [21]

Melamine cyanurate rat, oral 4,100 mg/kg 4.1 [16]

Fructose (fruit sugar) rat, oral 4,000 mg/kg 4 [22]

Sodium molybdate rat, oral 4,000 mg/kg 4 [23]

Sodium chloride (table salt) rat, oral 3,000 mg/kg 3 [24]

Paracetamol (acetaminophen) mouse, oral 338 mg/kg 0.338 [25]

Delta-9-tetrahydrocannabinol (THC) rat, oral 1270 mg/kg 1.27 [26]

Cannabidiol (CBD) rat, oral 980 mg/kg 0.98 [27]

Metallic Arsenic rat, oral 763 mg/kg 0.763 [28]

Ibuprofen rat, oral 636 mg/kg 0.636 [29]

Formaldehyde rat, oral 600–800 mg/kg 0.6 [30]

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