Question

the benifits of M-STRONG PG

Answer 1

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.

Pharmacology
Pharmacokinetics: Pregabalin (M STRONG PG) is rapidly absorbed after oral doses and peak plasma concentrations are achieved within 1.5 hrs.

Oral bioavailability is about 90%. The rate but not the extent of absorption is reduced if given with food but this is not clinically significant. Steady-state is achieved after 1-2 days. Pregabalin (M STRONG PG) is not bound to plasma proteins and undergoes negligible metabolism. About 98% of a dose is excreted in the urine as unchanged drug. The mean elimination half-life is 6.3 hrs. Pregabalin (M STRONG PG) is removed by hemodialysis.

Methylcobalamin (M STRONG PG) substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract. Absorption is impaired in patients with an absence of intrinsic factor, with a malabsorption syndrome or with disease or abnormality of the gut, or after gastrectomy. Absorption from the gastrointestinal tract can also occur by passive diffusion; little of the vitamin present in food is absorbed in this manner although the process becomes increasingly important with larger amounts eg, those used therapeutically. After intranasal dosage, peak plasma concentrations of cyanocobalamin have been reached in 1-2 hrs. The bioavailability of the intranasal preparation is about 7-11% of that by IM injection.

Vitamin B12 is extensively bound to specific plasma proteins called transcobalamins; transcobalamin II appears to be involved in the rapid transport of the cobalamins into tissues. Vitamin B12 is stored in the liver, excreted in the bile and undergoes extensive enterohepatic recycling; part of a dose is excreted in the urine, most of it in the first 8 hrs; urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means. Vitamin B12 diffuses across the placenta and also appears in breast milk.