The binding of oxygen to hemoglobin is affected by
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Allosteric Effectors of Oxygen Binding to Hemoglobin. Several factors influence the binding of oxygen to hemoglobin: temperature, pH, PCO2 and 2,3 diphosphoglycerate (2,3 DPG). Increasing the temperature of Hb lowers its affinity for O2 and shifts the oxygen dissociation curve to the right, as shown in Figure 3.
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high altitude or sickeal cell Anemia.
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