Question

The deficiency of which of the following cause the immunodeficiency. A. hypoxanthine-guanine transferase B.xanthine oxidase C.PRPP synthatase D.adeninosine deaminase

KINDLY ANSWER. EVEN CORRECT OPTION WITHOUT EXPLANATION IS APPRECIATED IN THIS QUESTION. I'LL MARK IT BRAINLY!​

Answer 1

Explanation:

Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzymatic deficiency. The prevalence is estimated at 1/380,000 live births in Canada, and 1/235,000 live births in Spain. Uric acid overproduction

is present inall HPRT-deficient patients and is associated with lithiasis and gout. Neurological manifestations include severe action dystonia, choreoathetosis, ballismus, cognitive and attention deficit, and self-injurious behaviour. The most severe forms are known as Lesch-Nyhan syndrome (patients are normal at birth and diagnosis can be accomplished when psychomotor delay becomes apparent).