The disadvantages of chemotherapy are possible bacterial resistance and side effects after systemic administration. Photodynamic therapy avoids these drawbacks by combining irradiation with the soft laser with the photosensitized dye. Methylene blue was chosen as a photosensitizer in this study, as it has been shown to be potentially one of the safest photosensitizers for the treatment of periodontal disease. It has a complementary benefit on sites with deep periodontal pockets, furcations and root concavity.
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