The drug interferes with the transport of dopamine in the nervous system is
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For example, nicotine stimulates cells directly by activating their receptors for acetylcholine, and indirectly by inducing higher levels of glutamate, a neurotransmitter that acts as an accelerator for neuron activity throughout the brain.
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Cocaine. The dopamine transporter, which is also known as SLC6A3 or DAT or the dopamine active transporter is a membrane-spanning protein which pumps the neurotransmitter dopamine out of the cleft back into cytosol.
Within the cytosol, some other transporters sequences the dopamine into the vesicles for placing it there for some time and later release. Cocaine is a strong stimulant that is generally used by people as a recreational drug.
Cocaine is generally smoked or inhaled, dissolved, snorted or injected into the vein. It acts by stopping the reuptake of dopamine, norepinephrine, and serotonin.
The concentration of the chemical increase significantly within the brain and hence it interferes in the transport of dopamine.
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