Question

The effect of protein-binding interactions

Answer 1

Answer:

The effect of protein binding interaction may result in clinically significant changes in the pharmacokinetics and pharmacodynamics of a drug. ...

Such protein binding interaction can result in displacement of warfarin from the protein binding site, increase free plasma concentrations and raise the risk of bleeding.

Answer 2

Answer:

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Displacement of drugs from binding sites simultaneously in both the plasma and in the tissues will combine the effects seen after displacement from the separate areas. Due to decreased binding in both areas, the free drug concentration in the plasma will increase leading to overactivity of the displaced drug