The effect of the hormone glucagon on the enzyme pyruvate kinase can best be described as
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Glucagon stimulates gluconeogenesis in part by decreasing the rate of phosphoenolpyruvate disposal bypyruvate kinase. ... Glucagonregulation of these two enzymeactivities is brought about primarily by changes in the level of a novel sugar diphosphate, fructose 2,6-bisphosphate.
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