Question

the g protein-coupled receptor kinase (grk) interac- tome: role of grks in gpcr regulation and signaling

Answer 1

G protein-coupled receptor kinases(GRKs) and arrestins are key participants in the canonical pathways leading to phosphorylation-dependentGPCR desensitization, endocytosis, intracellular trafficking and resensitization as well as in the modulation of important intracellularsignaling cascades by GPCR.


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