Question

the key control point of fatty acid synthesis is acetyl CoA caboxylase . given reason?​​​

Answer 1

Answer:

Acetyl CoA carboxylase plays an essential role in regulating fatty acid synthesis and degradation. Recall that this enzyme catalyzes the committed step in fatty acid synthesis: the production of malonyl CoA (the activated two-carbon donor).

Explanation:

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Answer 2

Answer:

Fatty acid metabolism is stringently controlled so that synthesis and degradation are highly responsive to physiological needs. Fatty acid synthesis is maximal when carbohydrate and energy are plentiful and when fatty acids are scarce. Acetyl CoA carboxylase plays an essential role in regulating fatty acid synthesis and degradation. Recall that this enzyme catalyzes the committed step in fatty acid synthesis: the production of malonyl CoA (the activated two-carbon donor). The carboxylase is controlled by three global signals—glucagon, epinephrine, and insulin—that correspond to the overall energy status of the organism. Insulin stimulates fatty acid synthesis by activating the carboxylase, whereas glucagon and epinephrine have the reverse effect. The levels of citrate, palmitoyl CoA, and AMP within a cell also exert control. Citrate, a signal that building blocks and energy are abundant, activates the carboxylase. Palmitoyl CoA and AMP, in contrast, lead to the inhibition of the carboxylase. Thus, this important enzyme is subject to both global and local regulation. We will examine each of these levels of regulation in turn.

Explanation:

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