the Krebs cycle in detail
Answers
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The Krebs cycle is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidization of acetate—derived from carbohydrates, fats, and proteins —into carbon dioxide. Theoretically there are several alternatives to the TCA cycle, but the TCA cycle appears to be the most efficient.
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Krebs cycle :-
Pyruvic acid produce during Glycolysis undergoes aerobic oxidation in the mitochondrial matrix through TCA cycle.
It is common oxidative pathway for carbohydrate, fat, proteins.
Intermediate compounds are used in synthesis of glutamate and asprated.
First pyruvic acid enter into mitochondria then it is decarboxylated and remaining 2 carbon fragment combines with Co enzyme A to form acetyl Co - A.
It is oxidative decarboxylation process which produces
ions, electrons and carbon dioxide.
oxidation of fatty acid produces acetyl co - A.
Acetyl Co-A condensed with oxyaloacetate to form citric acid.
The mitochondrial enzyme envoled to oxidise citric acid and releases carbon dioxide and oxyaloacetate regenerated again to complete cycle.
In this cycle 4 steps of oxidation is carried by dehydrogenase using an enzyme
and
Co enzymes are produced to
and
. This transfer their electron to the mitochondrial respiratory chain.