Question

The loading dose (DL) of a drug is usually based on the
Qotions​

Answer 1

The loading dose (DL) of a drug is usually based upon the following things:-

• It depends upon the percentage of the drug bound to the plasma proteins.
• Depends upon the apparent volume of the distribution i.e. 'VD' and desired drug concentration in plasma.
• Depends on the total body clearance (CIT) of the drug.
• Also depends on the area under the plasma drug concentration versus time curve (AUC).
• The dose rate needed to maintain the concentration within the window and would produce toxic concentrations if given in repeated dosed.

Answer 2

Explanation:

In medical treatments, loading dose is that which is given at a much higher concentration than the normal dose. This is given only at the beginning of the treatment Its dosage is mainly decided by how much quickly serum opioid concentration needs to be approached which provides effective pain control. It also depends on the amount of plasma to which it is to be attached