the main cause of congenital disease is due to a
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Approximately 50% of congenital anomalies cannot be linked to a specific cause. However, known causes include single gene defects, chromosomal disorders, multifactorial inheritance, environmental teratogens and micronutrient deficiencies. Genetic causes can be traced to inherited genes or from mutations.
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Aᴘᴘʀᴏxɪᴍᴀᴛᴇʟʏ 50% ᴏғ ᴄᴏɴɢᴇɴɪᴛᴀʟ ᴀɴᴏᴍᴀʟɪᴇs ᴄᴀɴɴᴏᴛ ʙᴇ ʟɪɴᴋᴇᴅ ᴛᴏ ᴀ sᴘᴇᴄɪғɪᴄ ᴄᴀᴜsᴇ. Hᴏᴡᴇᴠᴇʀ, ᴋɴᴏᴡɴ ᴄᴀᴜsᴇs ɪɴᴄʟᴜᴅᴇ sɪɴɢʟᴇ ɢᴇɴᴇ ᴅᴇғᴇᴄᴛs, ᴄʜʀᴏᴍᴏsᴏᴍᴀʟ ᴅɪsᴏʀᴅᴇʀs, ᴍᴜʟᴛɪғᴀᴄᴛᴏʀɪᴀʟ ɪɴʜᴇʀɪᴛᴀɴᴄᴇ, ᴇɴᴠɪʀᴏɴᴍᴇɴᴛᴀʟ ᴛᴇʀᴀᴛᴏɢᴇɴs ᴀɴᴅ ᴍɪᴄʀᴏɴᴜᴛʀɪᴇɴᴛ ᴅᴇғɪᴄɪᴇɴᴄɪᴇs. Gᴇɴᴇᴛɪᴄ ᴄᴀᴜsᴇs ᴄᴀɴ ʙᴇ ᴛʀᴀᴄᴇᴅ ᴛᴏ ɪɴʜᴇʀɪᴛᴇᴅ ɢᴇɴᴇs ᴏʀ ғʀᴏᴍ ᴍᴜᴛᴀᴛɪᴏɴs.
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