the major difference between primary and secondary lymphoid organ
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The central or primary lymphoid organs generate lymphocytes from immature progenitor cells. ...Secondary lymphoid tissues are also where lymphocytes are activated.
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The other primary lymphoid tissue is the thymus, the site where progenitor cells from the marrow differentiate into mature thymus-derived (T) cells. Secondary lymphoid tissues are sites where lymphocytes interact with each other and nonlymphoid cells to generate immune responses to antigens
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