The malarial parasites initially multiply within the liver cells and then attack the red blood cells (RBCs) resulting in their rupture. The rupture of RBCs is associated with release of
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The ruptured RBC's release hemozoin. Hemozoin is a crystalline, brown pigment that is formed and sequestered in the digestive vacuole of Plasmodium as a product of hemoglobin (Hb) catabolism.
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