The membrane resting potential is mainly determined by the
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The resting membrane potential is the voltage across a given cell membrane during the resting stage. In neuromuscular tissues (e.g., nerves, cardiac and skeletal muscle), it is determined primarily by the potassium concentration gradient across the cell membrane or the ratio of ICF to ECF potassium
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The resting membrane potential is determined mainly by two factors: the differences in ion concentration of the intracellular and extracellular fluids and. the relative permeabilities of the plasma membrane to different ion species.
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