The mucus and bicarbonates present in a gastric juice plays a protective role by preventing gastric epithelium from HCL . It is secreted by
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mucus and bicarbonate are secreted by goblet cells (or mucus cells) in the stomach's gastric pits
HCl secreted by parietal cells of the stomach
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In the stomach several mucosal defence mechanisms protect the stomach against hydrochloric acid and noxious agents. The pre-epithelial protection is made up by the mucus-bicarbonate barrier. Mucus and bicarbonate, secreted by mucus cells, create a pH gradient maintaining the epithelial cell surface at near neutral pH.
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