Question

the mutant haemoglobin molecule undergoes polymerisation under low oxygen tension .please explain ​

Answer 1

The hemoglobin molecules polymerize and form crystals as oxygen concentration is .... Practice: Understanding cardiac pressure- volume curves ... Practice: Tension in the muscles.

Answer 2

Answer:

In sickle cell anemia, the hemoglobin defects where the mutation or transversion has occurred.

Explanation:

In sickle cell anemia, the hemoglobin defects where the mutation or transversion has occurred. In the mutation, the glutamic acid i.e. Glu is replaced by Valine i.e. Val at the 6th position of the β-chain of hemoglobin. Due to this mutation, the molecules undergo polymerization under hypoxic or low oxygen conditions. This resulted in the disrupted shape of Erythrocytes from biconcave to curve or sickle-shaped cells.

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