The new individual inherits bone cheresteeristics from
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Answer:
The inherited bone marrow failure syndromes are a heterogeneous group of disorders characterized by bone marrow failure usually in association with one or more somatic abnormality. The bone marrow failure (which can involve all or a single cell lineage) often presents in childhood but may not do so until adulthood in some cases. Furthermore, some patients initially labeled as having “idiopathic aplastic anemia” actually have cryptic presentations of these genetic syndromes. Over the last two decades there have been considerable advances in the genetics of these syndromes with 33 genes having been identified to date. These advances have provided a better understanding of normal hematopoiesis and how this is disrupted in patients with bone marrow failure. They have also provided important insights into fundamental biological pathways: DNA repair-FA/BRCA pathway; telomere maintenance- dyskeratosis congenita-related genes; ribosome biogenesis-Shwachman Diamond syndrome (SDS) and Diamond-Blackfan anemia (DBA) genes. Additionally, as these disorders are usually associated with developmental abnormalities and an increased risk of cancer they are providing insights into human development and the genesis of cancer.