The oxidation and phosphorylation of intact mitochondria is inhibited by
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Cyanide can be lethal because it binds to the ferric form of cytochrome oxidase and thereby inhibits oxidative phosphorylation. Nitrite converts ferrohemoglobin into ferrihemoglobin, which also binds cyanide. Thus, ferrihemoglobin competes with cytochrome oxidase for cyanide.
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