The oxygenated and deoxygenated blood gets mixed in the heart.
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A hole between the two sides of the heart produces an abnormal mixture of oxygenated blood from the pulmonary circulation and deoxygenated blood from the systemic circulation. ... Right heart failure may then develop, and the supply of appropriately oxygenated blood to the body tissues may become compromised.
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If deoxygenated blood mixes with oxygenated blood, both lungs and tissues would receive blood with the same amounts of oxygen, which would affect the efficiency of the delivery of O2 to the tissues of the body.
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