Question

The role of calcium in coagulation and anticoagulation

Answer 1

Answer:

The role of calcium in coagulation anticoagulation.The quality of the coagulation related blood derived product is markedly affected by the manner in which blood is affected. Anticoagulation solutions contain citrate which efficiently prevent blood clotting by chelation of calcium and other metals ions.

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Answer 2

Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, and dialysis equipment. They can also be used as rodenticides.

in simply

Standard anticoagulation solutions contain citrate which efficiently prevents blood clotting by chelation of calcium and other metal ions. ... For instance,chelation of calcium leads to conformational changes of the coagulation factors V and VIII which results in loss of the procoagulant activity.