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The role of dendritic cells and monocytes in hcv infection and hiv/hcv co-infection​

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Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

Published: 01 June 2004

Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

Justin STEBBING, Steve PATTERSON, […]Brian GAZZARD

Cell Research volume 14, pages251–256(2004)Cite this article

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ABSTRACT

There is increasing recognition of the potential morbidity and mortality associated with HIV-1 and hepatitis C (HCV) co-infection. HIV appears to adversely affect HCV disease while the reciprocal effect of HCV on HIV remains controversial. We therefore studied the effect of co-infection on dendritic cell function versus HIV infection alone, as previous work has shown that HCV impairs dendritic cell (DC) function. HIV-1 positive individuals with HCV were matched for CD4 count, HIV-1 RNA viral load and therapy, to HIV-1 positive patients without HCV. Monocyte-derived DC were generated and mixed leukocyte reactions were performed. We assessed allostimulatory capacity with and without administration of exogenous Th1 cytokines, using thymidine uptake and cell division analyses with the vital dye CFSE. We found that monocyte-derived DC from co-infected individuals showed no significant differences in allostimulatory capacity to ex vivo generated DC from HIV-1 infected individuals without HCV. Unlike the situation with HCV infection alone, this impairment was not reversed by increasing concentrations of either interleukin-2 or -12. Monocyte-derived DC from HIV-1 and HCV co-infected

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