The toxic effects of co due to affinity for haemoglobin
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The etiology of CO toxicity is due to its effects on oxygen binding to the haemoglobin molecules. carbon monoxide combines with haemoglobin has more affinity with hemoglobin than oxygen.
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- The toxic effects of CO is due to higher affinity for haemoglobin than Oxygen.
Explanation:
- Carbon monoxide is produced due to incomplete combustion, metallurgical operations and naturally by plants as well as animals.
- Carbon monoxide has 200 times more affinity to haemoglobin as compared to oxygen.
- Carbon monoxide combines with haemoglobin of blood and forms a stable compound called carboxyhaemoglobin.
- At 50 ppm, CO converts 7.5% of haemoglobin into carboxyhaemoglobin within 8 hours.
- It impairs oxygen transport resulting in headache, decreased vision, cardiovascular malfunction and asphyxia.
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