the___which are normally biconcave becomes sickle shaped
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Sickle Cell Disease/ Anaemia
The RBCs are produced in bone marrow and average life of normal RBCs is about 120 days. Biconcave disc shape of RBCs changes to sickle shape under low oxygen tension due to polymerization of faulty haemoglobin called HbS arising out of a point mutation in beta globin gene.
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