Theimportanceofapc(anaphasepromoting complex)infertilizationis that
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Answer:
The APC/C's main function is to trigger the transition from metaphase to anaphase by tagging specific proteins for degradation. The three major targets for degradation by the APC/C are securin and S and M cyclins. Securin releases separase (a protease) after being degraded. The separase triggers the cleavage of cohesin, the protein complex that binds sister chromatids together. During metaphase, sister chromatid is linked by intact cohesin complexes. When securin undergoes ubiquitination by the APC/C and releases separase, which degrades cohesin, sister chromatids become free to move to opposite poles for anaphase. The APC/C also targets the mitotic cyclins for degradation, resulting in the inactivation of M-CDK (mitotic cyclin-dependent kinase) complexes, promoting exit from mitosis and cytokinesis.
Answer:
This ensures that each daughter cell receives the proper complement of chromosomes. The anaphase-promoting complex (APC) is a multisubunit protein complex with ubiquitin ligase activity that regulates chromosome segregation and anaphase progression by targeting key factors for degradation.