to determine tha solubility of given unknown polymer samples in givem known solvent
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For unknown sample solubility done by water bath method or USP shaking flask method (37 or 25 degree temperature), excess amount of drug u can use in fixed amount of solvent ( water or buffer in different pH). then run the machine with a high speed rotation. Depending upon your experiment design, you can collect the sample in different time interval or after 24 or 48 hrs later. after that u can check your sample by HPLC or UV spectroscopy under a validated method.
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