Question

Tpa-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin

Answer 1

✪The activator protein-1 (AP-1) family of transcription factors contributes to regulation of numerous genes involved in proliferation, apoptosis, and tumorigenesis.
✪A wide array of stimuli can activate AP-1, including pro-inflammatory cytokines, growth factors, tumor promoters and stress.
✪Numerous plant polyphenols have been shown to inhibit the activation of AP-1, which often is ascribed to the anti-oxidant properties of these natural products.

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