Question

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

Answer 1

SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 ,2 In tumors of epithelialcell origin — carcinomas — a basement membrane is often interposed between the tumor cells and the stroma, but in other types of tumors, malignant cells directly abut on or intermingle with stromal elements.1 , 3 An appreciation of tumor stroma is essential to an understanding of the biology of tumor growth; all solid tumors, regardless of their site of origin, require stroma if they are to grow beyond a minimal size of . . .

Answer 2

❣️$\huge\underline\mathfrak{heya}$❣️

Successful tumors - that is, tumors that grow progressively in the host - are obligate parasites. They have developed the capacity to preempt and subvert the wound-healing response of the host as a means to acquire the stroma they need to grow and expand. They mimic wounds by depositing an extravascular fibrin-fibronectin gel. Such gels, in tumors as at sites of local injury, signal the host to marshal the wound-healing response. This response is stereotyped and similar in both tumors and wounds. In tumors, however, the fibrin-fibronectin matrix signal that evokes the wound-healing response is not self-limited; it continues to operate and new gel is continuously deposited. Thus, tumors appear to the host in the guise of wounds or, more correctly, of an unending series of wounds that continually initiate healing but never heal completely.

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