Two children, A and B aged 4 and 5 years respectively visited a hospital with a similar genetic disorder. The girl A was provided enzyme-replacement therapy and was advised to revisit periodically for further treatment. The girl, B was, however, given atherapy that did not require revisit for further treatment.
(a) Name the ailments the two girls were suffering from?
(b) Why did the treatment provided to girl A required repeated visits?
(c) How was the girl B cured permanently?
Answers
Answer:
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Enzyme-replacement therapy
Explanation:
a) The infection referenced here is ADA (adenosine deaminase) lack which is caused because of change in quality that code for ADA proteins. The inadequacy of these compounds causes annihilation of B and T lymphocytes which brings about the feeble insusceptible system.
(b) Girl A must be given Enzyme Replacement Therapy in which lymphocytes are disconnected from a patient's body and afterward refined in-vitro. In the refined lymphocytes, the ADA cDNA is brought and afterward embedded go into the patient's body. Be that as it may, since lymphocytes pass on after a specific time frame, rehashed imbuements are given to the patient.
(c) Girl B must be given Gene Therapy where the quality secluded from bone marrow cells delivering ADA is brought into cells at undeveloped stages which is permanent core.