under what condition does a molecule show a strong tendency to hydrolyse in water
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Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other. It often but not always involves some chemical bonding.
In some cases, the associations can be quite strong—for example, the protein streptavidinand the vitamin biotin have a dissociation constant (reflecting the ratio between bound and free biotin) on the order of 1014—and so the reactions are effectively irreversible. The result of molecular binding is sometimes the formation of a molecular complex in which the attractive forces holding the components together are generally non-covalent, and thus are normally energetically weaker than covalent bonds.
Molecular binding occurs in biological complexes (e.g., between pairs or sets of proteins, or between a protein and a small molecule ligand it binds) and also in abiologic chemical systems, e.g. as in cases of coordination polymers and coordination networks such as metal-organic frameworks.
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In some cases, the associations can be quite strong—for example, the protein streptavidinand the vitamin biotin have a dissociation constant (reflecting the ratio between bound and free biotin) on the order of 1014—and so the reactions are effectively irreversible. The result of molecular binding is sometimes the formation of a molecular complex in which the attractive forces holding the components together are generally non-covalent, and thus are normally energetically weaker than covalent bonds.
Molecular binding occurs in biological complexes (e.g., between pairs or sets of proteins, or between a protein and a small molecule ligand it binds) and also in abiologic chemical systems, e.g. as in cases of coordination polymers and coordination networks such as metal-organic frameworks.
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