Under which of the following conditions will there be no change in the reading frame of following MRNA?
Answers
wild-type 5’-AUGCAUACAUUGGAGUGA-3’
mutant 5’-AUGCAUACAUCUGGAGUGA-3’
Explanation:
Frame shift mutation as the name indicates are such type of mutation in which a nucleotide insertion or deletion occurs in such as way that it alters the complete sequence of 3 codon sets. As we know all the genes are translated in sets of 3 codons, which determine a specific amino acid sequence. So, if a frame shift mutation occurs, unlike a point mutation it can effect many amino acid sequences and ultimately a whole protein.
If we look at option C:
wild-type 5’-AUG CAU ACA UUG GAG UGA-3’
mutant 5’- AUG CAU ACA UCU GGA GUG A-3’
An insertion of a base Uracil occured at the end of 3rd codon due to which whole sequence of codon triplets were altered. This changed all next codons and ultimately all next amino acids will be altered.
Hope it helps!!!
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HELLO ❤️
Your question is incomplete...
but still I can't let you waste your points like that, so, i can show you Protein synthesis mechanism (reading and all) on mRNA.
I JUST HOPE THIS IS A BIT HELPFUL ❤️...
(AND YEA.. COMPLETE YOUR QUESTION IN COMMENT SECTION)