Biology, asked by Anonymous, 1 year ago

URGENT..........................
WHY WE USE ONLY ATP AS ENERGY , WHY WE DON'T USE CTP , GTP , TTP AS ENERGY SOURCE .

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Answered by smitpandhare43pbe9lt
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Hey Mate!!! Here's your answer...



Why is ATP the only energy currency of the cell? Why not CTP, GTP, or UTP?
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2 ANSWERS
Rajashree Biswal
Rajashree Biswal, Student at Biology
Answered Apr 27, 2017
Relevant to separate ATP and GTP, which are both purines, from UTP, CTP, and TTP which are pyrimidines. ATP was random or was just thermodynamically the most favorable, but I can shed light on where other nucleotides are used in metabolism. size of the purine base would give it different binding properties (larger hydrophobic surface area) than the smaller pyrimidines.

The evolution of ATP was related to energy first before life development in the earliest time at 4.2 billion years ago, while the evolution of GTP was later because it needed oxygen atom in the GTP molecule (remember, the oxygen level in the atmosphere was very low at that earlier time!). That means the signalling function of cells was developed much later than the energy production in the mitochondria.

The next useful thing to notice is that both ATP and GTP act as both energy currency and signal molecules (i.e. there are signal pathways that form cyclic AMP to carry signals, and signal pathways that form cyclic GMP, etc.). Structurally, these two molecules perform each other's functions in many different circumstances.

As to why ATP ended up heavily favored as an energy currency as opposed to GTP, which is more favored in common signaling pathways, I can only offer two observations that might be factors:

The body needs to have some way to use energy for signalling and to use energy for other purposes. Since GTP and ATP are both present at the same time, it makes sense to specialize one for one task and the other for the other.
In DNA and RNA, Adenine forms only two hydrogen bonds with the pyrimidines T and U whereas Guanine forms three with C. Therefore, if you simply had to choose which nucleotide to use for bulk energy transactions between A and G, it would make sense to choose A because there is slightly less energy required to separate it from its binding partner in structures (which would be a benefit when you want to isolate it and use it as an energy molecule).




Hope that it will help you...
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