Question

व्हाट इज द फार्मूला ऑफ पीस​

Answer 1

Answer:

When calculating the PIC, you first calculate heterozygosity, i.e. one minus the squared allele frequencies. For an SNP this is simply 1-(maf^2+(1-maf)^2). Then you substract a term for identically heterozygous trios, which for an SNPs is just 2*maf^2*(1-maf)^2.