Question

Vaccine Against Measles Will Not Protect A Child From Hepatitis. Why

Answer 1

Answer:

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Explanation:

As is observed for residual immunity to live vaccines, in particular against measles, after the end of therapy patients generally have lower levels of protection compared to the residual protection against the tetanus, polio and diphtheria vaccines(3,4). The reported percentage of protection against measles is never greater than 75% among cohorts and the median values of protection are around 60%(3). Some authors point out that the ability to respond to measlesrevaccination is seriously compromised due to the chemotherapy schedule that is adopted to treat leukaemia. One hypothesis, formulated by Nilsson et al.(5) is that depletion of antigenspecific B memory and plasma cells in the bone marrow compromises the ability to respond to the booster thus leading to a lack of specific antibody levels. Moreover, low responders to boosters seem to show both quantitative and qualitative defects in terms of low avidity of the antibodies to measles antigens(5). Some authors sustain that the children who were not protected following chemotherapy were younger at the time of diagnosis than those who showed protective values(6,7).

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