Question

various solubility enhancement techniques in liquid dosage form ​

Answer 1

Answer:

Kneading Technique: In this technique, cyclodextrin (CD) is impregnated with water and converted to paste. Drug is then added and kneaded for specified time. The kneaded mixture is then dried and passed through sieve if required .

Co-precipitation: Required amount of drug is added to the solution of β-CD. The system is kept under magnetic agitation with controlled process parameters and protected from the light. The formed precipitate is separated by vacuum filtration and dried at room temperature in order to avoid the loss of the structure water from the inclusion complex .

Neutralization: Drug is added in alkaline solution like sodium hydroxide, ammonium hydroxide. A solution of β- Cyclodextrin is then added to dissolve the joined drug. The clear solution obtained after few seconds under agitation is neutralized using HCl solution until reaching the equivalence point. At this moment, the appearance of a white precipitate could be appreciated, corresponding to the formation of the inclusion compound. The precipitate is then filtered and dried .

Co-grinding: Drug and cyclodextrin are mixed and the physical mixture is introduced in a suitable mill like oscillatory mill and grinded for suitable time .

Spray-Drying Method: Drug is dissolved in suitable solvent and the required stoichiometric amount of carrier material like β-cyclodextrin is dissolved in water. Solutions are then mixed by sonication or other suitable method to produce a clear solution, which is then spray dried .

Microwave Irradiation Method: Drug and cyclodextrins mixture is reacted in microwave oven to form inclusion. It is a novel method for industrial scale preparation due to its major advantage of shorter reaction time and higher yield of product .