Question

What are lysosomal storage diseases? Give example.
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Answer 1

Answer:

Lysosomal storage diseases are inherited metabolic diseases that are characterized by an abnormal build-up of various toxic materials in the body's cells as a result of enzyme deficiencies.

Explanation:

Gaucher disease is one of the most common lysosomal storage disorders (LSDs). LSDs are inherited disorders resulting from a lack of specific enzymes that break down certain lipids (fats) or carbohydrates (sugars) in the body cells.

Gaucher's disease and Niemann-Pick disease are the most common storage diseases encountered in the bone marrow and both may cause the accumulation of patchy or diffuse aggregates of large histiocytes with abundant cytoplasm and small nuclei.

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