Question

What are opioid antidiarrhoeals? Give mechanism of action and SAR. (Medicinal Chemistry - lll)

Answer 1

Electrolyte solutions, while not true antidiarrhoeals, are used to replace lost fluids and salts in acute cases. ... Opioids' classical use besides pain relief is as an anti-diarrhoeal drug. Opioids have agonist actions on the intestinal opioid receptors, which when activated cause constipation

Answer 2

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Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostatin receptors.